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Plasma & IVIG

What is Plasma?

Plasma is yellow in color and is the liquid portion of blood in which all blood cells are suspended, representing approximately 55% of total blood volume. Plasma, which is 90% water, is rich in proteins used by the human body for blood clotting and fighting infection.

These proteins account for approximately 7% of plasma’s volume. As plasma contains these valuable proteins, plasma collection and the manufacturing of human plasma derived therapeutics provide therapeutic benefits for ill patients.

In order to produce plasma derived therapeutics that can be administered to patients in need, raw material source plasma must be collected from human donors and then manufactured, or fractionated into specialized therapeutic products.

Plasma is collected from healthy donors at FDA-licensed plasma donation centers. To ensure safety of the plasma supply, all plasma collections are tested using FDA-approved methods of Nucleic Acid Testing, or NAT, to exclude the presence of any infectious particles.

Blood & Plasma Composition



Plasma contains:

Protein and Water


Blood contains:

Plasma, Red Cells, White Cells and Platelets


Plasma proteins

  • Intravenous immunoglobulin (IVIG) is made from a key therapeutic protein in plasma: Immunoglobulin (IgG)
  • IgG = naturally occurring polyclonal antibodies against bacteria, fungus and viruses
  • Other therapeutic products made from plasma proteins include: albumin, coagulation factors, alpha 1, C 1 etc.

Composition of Blood:

blood composition


ADMA optimized Ig manufacturing process to include validation for all intermediate fractions, Maximizing revenue from each L of plasma

What Is Intravenous Immune Globulin (IVIG)?

Human immune globulin is comprised of antibodies—Y-shaped proteins produced by B-cells that are used by the body’s immune system to identify and neutralize foreign objects such as bacteria and viruses. IVIG is immune globulin purified from plasma by a manufacturing process called fractionation and administered intravenously to patients.


There are 2 types of immune globulins, standard and hyperimmune.

Standard Immune Globulins

Standard immune globulins are manufactured using normal source plasma.

Hyperimmune Immune Globulins

Manufactured using plasma obtained from donors who have elevated amounts [high- titers] of specific antibodies against a targeted pathogen.


Additionally, IVIG is also used as therapy in a variety of other diseases that do not involve primary or secondary immune deficiencies, such as multiple sclerosis, skin diseases, and asthma. These latter uses are referred to as “off-label” or evidence-based uses because the FDA has not approved their use in these indications and promotion of such uses is not permitted by FDA unless approved by the agency.

Learn more about ADMA Biocenters and Plasma Donation

Learn more about ADMA Biocenters and Plasma Donation

Additional information on plasma composition and donation can be found at www.admabiocenters.com

ADMA BioCenters is an FDA licensed facility specializing in the collection of human plasma used to make special medications for the treatment and prevention of diseases.