Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($)
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2019 $ 5,932 $ 290,903,772 $ (264,716,555) $ 26,193,149
Balance (in shares) at Dec. 31, 2019 59,318,355      
Increase (Decrease) in Stockholders' Equity [Roll Forward]        
Stock-based compensation $ 0 2,855,122 0 2,855,122
Warrants issued in connection with note payable 0 3,740,980 0 3,740,980
Vesting of restricted stock units $ 2 (2) 0 0
Vesting of restricted stock units (in shares) 15,000      
Issuance of common stock, net of offering expenses $ 4,555 131,190,736 0 131,195,291
Issuance of common stock, net of offering expenses (in shares) 45,562,907      
Stock options exercised $ 1 13,431 0 13,432
Stock options exercised (in shares) 6,626      
Net loss $ 0 0 (75,748,548) (75,748,548)
Balance at Dec. 31, 2020 $ 10,490 428,704,039 (340,465,103) 88,249,426
Balance (in shares) at Dec. 31, 2020 104,902,888      
Increase (Decrease) in Stockholders' Equity [Roll Forward]        
Stock-based compensation $ 0 3,488,253 0 3,488,253
Vesting of restricted stock units, net of shares withheld for taxes and retired $ 6 (61,604) 0 (61,598)
Vesting of restricted stock units, net of shares withheld for taxes and retired (in shares) 64,900      
Issuance of common stock, net of offering expenses $ 9,085 121,135,018 0 121,144,103
Issuance of common stock, net of offering expenses (in shares) 90,846,029      
Net loss $ 0 0 (71,647,618) (71,647,618)
Balance at Dec. 31, 2021 $ 19,581 $ 553,265,706 $ (412,112,721) $ 141,172,566
Balance (in shares) at Dec. 31, 2021 195,813,817