Quarterly report pursuant to Section 13 or 15(d)

STOCKHOLDERS' EQUITY, Equity Incentive Plans (Details)

v3.21.2
STOCKHOLDERS' EQUITY, Equity Incentive Plans (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period     4 years  
Total stock-based compensation expense, Amount [Abstract]        
Total stock-based compensation expense $ 805,189 $ 715,608 $ 1,586,586 $ 1,392,156
Research and Development [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Total stock-based compensation expense 42,479 105,029 147,706 198,603
Plasma Center Operating Expenses [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Total stock-based compensation expense 13,637 8,510 24,455 15,754
Selling, General and Administrative [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Total stock-based compensation expense 665,836 539,256 1,254,327 1,063,145
Cost of Product Revenue [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Total stock-based compensation expense 83,237 $ 62,813 160,098 $ 114,654
Equity Incentive Plans [Member]        
Stock Options, Weighted Average Exercise Price [Abstract]        
Unrecognized compensation expense, stock options $ 4,200,000   $ 4,200,000  
Unrecognized compensation expense recognition period     2 years 7 months 6 days  
Stock Options [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Volatility     69.00%  
Dividend yield     0.00% 0.00%
Stock Options [Abstract]        
Number of stock options granted (in shares)     1,658,050 1,232,500
Weighted average remaining contractual life of stock options, outstanding     6 years 6 months  
Weighted average remaining contractual life of stock options, expected to vest     6 years 6 months  
Weighted average remaining contractual life of stock options, exercisable     5 years 2 months 12 days  
Stock Option, Shares [Abstract]        
Options outstanding, vested and expected to vest, beginning balance (in shares)     6,922,931  
Forfeited (in shares)     (404,782)  
Expired (in shares)     (393,170)  
Granted (in shares)     1,658,050  
Exercised (in shares)     0  
Options outstanding, vested and expected to vest, ending balance (in shares) 7,783,029   7,783,029  
Options exercisable (in shares) 5,011,506   5,011,506  
Stock Options, Weighted Average Exercise Price [Abstract]        
Options outstanding, vested and expected to vest, weighted average exercise price, beginning balance (in dollars per share)     $ 4.40  
Forfeited, weighted average exercise price (in dollars per share)     2.96  
Expired, weighted average exercise price (in dollars per share)     5.03  
Granted, weighted average exercise price (in dollars per share)     2.26  
Exercised, weighted average exercise price (in dollars per share)     0  
Options outstanding, vested and expected to vest, weighted average exercise price, ending balance (in dollars per share) $ 3.98   3.98  
Options exercisable, weighted average exercise price (in dollars per share) $ 4.70   $ 4.70  
Stock Options [Member] | Minimum [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Expected term     5 years 6 months 5 years 6 months
Volatility       62.00%
Risk-free interest rate     0.80% 0.38%
Stock Options [Member] | Maximum [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Expected term     6 years 3 months 18 days 6 years 3 months 18 days
Volatility       67.00%
Risk-free interest rate     1.14% 1.68%
Restricted Stock Units (RSUs) [Member]        
Restricted Stock Units [Abstract]        
Number of restricted stock units granted (in shares)     542,244 341,000
Shares withheld for tax withholding obligation (in shares) 26,365   26,365  
Amount of shares withheld for tax withholding obligation $ 59,000   $ 59,000  
Unvested RSU, Shares [Abstract]        
Beginning balance (in shares)     326,000  
Granted (in shares)     542,244  
Vested (in shares)     (87,750)  
Forfeited (in shares)     (94,361)  
Ending balance (in shares) 686,133   686,133  
Unvested RSU, Weighted Average Grant Date Fair Value        
Unvested, Weighted average grant date fair value, beginning balance (in dollars per share)     $ 2.81  
Granted, Weighted average grant date fair value (in dollars per share)     2.29  
Vested, Weighted average grant date fair value (in dollars per share)     2.81  
Forfeited, Weighted average grant date fair value (in dollars per share)     2.53  
Unvested, Weighted average grant date fair value, ending balance (in dollars per share) $ 2.44   $ 2.44  
Restricted Stock Units (RSUs) [Member] | Directors [Member]        
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period       1 year
Restricted Stock Units (RSUs) [Member] | Employees [Member]        
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period     4 years  
Restricted Stock Units (RSUs) [Member] | Equity Incentive Plans [Member]        
Stock Options, Weighted Average Exercise Price [Abstract]        
Unrecognized compensation expense recognition period     3 years 3 months 18 days  
Unvested RSU, Weighted Average Grant Date Fair Value        
Unrecognized compensation expense, non option $ 1,500,000   $ 1,500,000