Annual report pursuant to Section 13 and 15(d)

10. INCOME TAXES (Details)

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10. INCOME TAXES (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]    
Benefit at U.S. Federal statutory rate $ (6,635,151) $ (6,109,776)
State taxes - deferred (266,312) (124,874)
Increase in valuation allowance, inclusive of true-ups 5,755,413 6,021,614
Research and development credits (322,499) (389,355)
Other 1,468,549 602,391
Benefit for income taxes $ 0 $ 0