Annual report pursuant to Section 13 and 15(d)

9. STOCK OPTIONS (Tables)

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9. STOCK OPTIONS (Tables)
 12 Months Ended
Dec. 31, 2016
Equity [Abstract]  
Schedule of stock options outstanding
    Year Ended   Year Ended
    December 31, 2016   December 31, 2015
        Weighted       Weighted
        Average       Average
        Exercise       Exercise
    Shares   Price   Shares   Price
 
Outstanding at beginning of period     1,464,203     $ 8.02       1,048,927     $ 7.24  
Forfeited     (21,334 )     8.02       (9,710 )   9.16  
Expired     (8,666 )     7.88       (7,514 )     6.55  
Granted     100,984       6.20       432,500       9.92  
Outstanding at end of period and expected to vest     1,535,187       7.90       1,464,203       8.02  
                                 
Options exercisable     1,179,143     $  7.64       880,457     $ 7.19  
Weighted average fair value of options                                
granted during the year           $ —               $ 5.25  
Stock-based compensation expense
    2016   2015
 
Research and development   $ 439,982     $ 724,776  
Plasma centers     52,973       48,386  
General and administrative     757,119       937,885  
Total stock-based compensation expense   $ 1,250,074     $ 1,711,047