Annual report pursuant to Section 13 and 15(d)

10. INCOME TAXES (Tables)

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10. INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2015
Income Tax Disclosure [Abstract]  
Schedule of reconciliation of income taxes
    Year Ended December 31,  
    2015     2014  
Benefit at US federal statutory rate   $ (6,109,776 )   $ (5,904,062 )
State taxes - deferred     (124,874 )     879,793  
Increase in valuation allowance, inclusive of true-ups     6,021,614       5,147,244  
Research and development credits     (389,355 )     (551,863 )
Sale of state net operating loss     -       (551,724 )
Other     602,391       428,888  
Benefit for income taxes   $ -     $ (551,724 )
Schedule of deferred tax asset
    December 31,  
    2015     2014  
Federal and state net operating loss carryforwards   $ 25,834,860     $ 21,004,587  
Federal and state research credits     4,353,534       3,649,268  
Accrued expenses and other     1,371,547       884,472  
Total gross deferred tax assets     31,559,941       25,538,327  
Less: valuation allowance for deferred tax assets     (31,559,941 )     (25,538,327 )
Net deferred tax assets   $ -     $ -