Annual report pursuant to Section 13 and 15(d)

10. INCOME TAXES (Details 1)

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10. INCOME TAXES (Details 1) (USD $)
Dec. 31, 2014
Dec. 31, 2013
Deferred tax assets:    
Federal and state net operating loss carryforwards $ 21,004,587us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic $ 16,791,893us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsDomestic
Federal and state research credits 3,649,268us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch 2,846,245us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
Accrued expenses and other 884,472us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals 752,945us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals
Total gross deferred tax assets 25,538,327us-gaap_DeferredTaxAssetsGross 20,391,083us-gaap_DeferredTaxAssetsGross
Less: valuation allowance for deferred tax assets (25,538,327)us-gaap_DeferredTaxAssetsValuationAllowance (20,391,083)us-gaap_DeferredTaxAssetsValuationAllowance
Net deferred tax assets $ 0us-gaap_DeferredTaxAssetsLiabilitiesNet $ 0us-gaap_DeferredTaxAssetsLiabilitiesNet