Annual report pursuant to Section 13 and 15(d)

INCOME TAXES, Reconciliation of Income Taxes (Details)

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INCOME TAXES, Reconciliation of Income Taxes (Details) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
INCOME TAXES [Abstract]    
Benefit at U.S. Federal statutory rate $ (15,045,999) $ (15,907,195)
State taxes - deferred (251,839) (3,797,393)
Increase in valuation allowance 14,618,762 19,535,265
Research and development credits (239,585) (246,989)
Decrease in federal net operating loss 623,679 0
Other 294,982 416,312
Benefit for income taxes $ 0 $ 0