Annual report pursuant to Section 13 and 15(d)

STOCKHOLDERS' EQUITY, Equity Incentive Plans (Details)

v3.22.1
STOCKHOLDERS' EQUITY, Equity Incentive Plans (Details) - USD ($)
12 Months Ended
Mar. 23, 2022
Dec. 31, 2021
Dec. 31, 2020
Jan. 01, 2022
Stock Options [Abstract]        
Shares reserved for grant (in shares)   87,241,078    
Number of stock options granted (in shares)   1,895,550 1,468,412  
Weighted average remaining contractual life of stock options, outstanding   6 years 1 month 6 days    
Weighted average remaining contractual life of stock options, expected to vest   6 years 1 month 6 days    
Weighted average remaining contractual life of stock options, exercisable   4 years 10 months 24 days    
Stock Option Outstanding and Exercisable [Abstract]        
Outstanding at beginning of period (in shares)   7,862,722    
Weighted average remaining contractual life of stock options, outstanding   6 years 1 month 6 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 3.93    
Options outstanding, aggregate intrinsic value   $ 35,935    
Options exercisable (in shares)   5,521,312    
Weighted average remaining contractual life of stock options, exercisable   4 years 10 months 24 days    
Options exercisable, weighted average exercise price (in dollars per share)   $ 4.54    
Options exercisable, aggregate intrinsic value   $ 4,831    
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period   4 years    
Total stock-based compensation expense, Amount [Abstract]        
Stock-based compensation   $ 3,488,253 $ 2,855,122  
Research and Development [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Stock-based compensation   153,924 471,146  
Plasma Center Operating Expenses [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Stock-based compensation   60,257 33,464  
Selling, General and Administrative [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Stock-based compensation   2,958,008 2,107,577  
Cost of Product Revenue [Member]        
Total stock-based compensation expense, Amount [Abstract]        
Stock-based compensation   $ 316,064 $ 242,935  
$1.10 - $1.67 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   9 years 7 months 6 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 1.10    
Exercise price range, upper limit (in dollars per share)   $ 1.67    
Outstanding at beginning of period (in shares)   352,500    
Weighted average remaining contractual life of stock options, outstanding   9 years 7 months 6 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 1.10    
Options outstanding, aggregate intrinsic value   $ 35,935    
Options exercisable (in shares)   15,583    
Weighted average remaining contractual life of stock options, exercisable   9 years 9 months 18 days    
Options exercisable, weighted average exercise price (in dollars per share)   $ 1.10    
Options exercisable, aggregate intrinsic value   $ 4,831    
$1.73 - $2.60 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   8 years 10 months 24 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 1.73    
Exercise price range, upper limit (in dollars per share)   $ 2.60    
Outstanding at beginning of period (in shares)   1,673,518    
Weighted average remaining contractual life of stock options, outstanding   8 years 10 months 24 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 2.42    
Options outstanding, aggregate intrinsic value   $ 0    
Options exercisable (in shares)   374,318    
Weighted average remaining contractual life of stock options, exercisable   8 years 6 months    
Options exercisable, weighted average exercise price (in dollars per share)   $ 2.42    
Options exercisable, aggregate intrinsic value   $ 0    
$2.62 - $3.93 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   5 years 10 months 24 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 2.62    
Exercise price range, upper limit (in dollars per share)   $ 3.93    
Outstanding at beginning of period (in shares)   4,209,177    
Weighted average remaining contractual life of stock options, outstanding   5 years 10 months 24 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 3.51    
Options outstanding, aggregate intrinsic value   $ 0    
Options exercisable (in shares)   3,554,848    
Weighted average remaining contractual life of stock options, exercisable   5 years 7 months 6 days    
Options exercisable, weighted average exercise price (in dollars per share)   $ 3.51    
Options exercisable, aggregate intrinsic value   $ 0    
$3.98 - $5.97 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   5 years 7 months 6 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 3.98    
Exercise price range, upper limit (in dollars per share)   $ 5.97    
Outstanding at beginning of period (in shares)   487,040    
Weighted average remaining contractual life of stock options, outstanding   5 years 7 months 6 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 5.07    
Options outstanding, aggregate intrinsic value   $ 0    
Options exercisable (in shares)   442,202    
Weighted average remaining contractual life of stock options, exercisable   5 years 4 months 24 days    
Options exercisable, weighted average exercise price (in dollars per share)   $ 5.07    
$6.02 - $9.03 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   1 year 1 month 6 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 6.02    
Exercise price range, upper limit (in dollars per share)   $ 9.03    
Outstanding at beginning of period (in shares)   892,987    
Weighted average remaining contractual life of stock options, outstanding   1 year 1 month 6 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 7.74    
Options outstanding, aggregate intrinsic value   $ 0    
Options exercisable (in shares)   886,861    
Weighted average remaining contractual life of stock options, exercisable   1 year    
Options exercisable, weighted average exercise price (in dollars per share)   $ 7.74    
$9.37 - $10.80 [Member]        
Stock Options [Abstract]        
Weighted average remaining contractual life of stock options, outstanding   2 years 10 months 24 days    
Stock Option Outstanding and Exercisable [Abstract]        
Exercise price range, lower limit (in dollars per share)   $ 9.37    
Exercise price range, upper limit (in dollars per share)   $ 10.80    
Outstanding at beginning of period (in shares)   247,500    
Weighted average remaining contractual life of stock options, outstanding   2 years 10 months 24 days    
Options outstanding, weighted average exercise price (in dollars per share)   $ 10.28    
Options outstanding, aggregate intrinsic value   $ 0    
Options exercisable (in shares)   247,500    
Weighted average remaining contractual life of stock options, exercisable   2 years 10 months 24 days    
Options exercisable, weighted average exercise price (in dollars per share)   $ 10.28    
Options exercisable, aggregate intrinsic value   $ 0    
2014 Omnibus Incentive Compensation Plan [Member]        
Stock Options [Abstract]        
Shares reserved for grant (in shares)   2,334,940    
Shares available for issuance (in shares)   69,090    
Equity Incentive Plans [Member]        
Stock Options [Abstract]        
Percentage of outstanding shares of common stock   4.00%    
Shares available for issuance (in shares)   10,000,000    
Stock Option Outstanding and Exercisable [Abstract]        
Unrecognized compensation expense, stock options   $ 3,100,000    
Unrecognized compensation expense recognition period   2 years 4 months 24 days    
Equity Incentive Plans [Member] | Subsequent Event [Member]        
Stock Options [Abstract]        
Shares available for issuance (in shares)       7,901,643
Stock Options [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Dividend yield   0.00% 0.00%  
Stock Option, Shares [Abstract]        
Options outstanding, vested and expected to vest, beginning balance (in shares)   6,922,931 5,630,351  
Forfeited (in shares)   (529,202) (141,724)  
Expired (in shares)   (426,557) (27,482)  
Granted (in shares)   1,895,550 1,468,412  
Exercised (in shares)   0 (6,626)  
Options outstanding, vested and expected to vest, ending balance (in shares)   7,862,722 6,922,931  
Options exercisable (in shares)   5,521,312    
Stock Options, Weighted Average Exercise Price [Abstract]        
Options outstanding, vested and expected to vest, weighted average exercise price, beginning balance (in dollars per share)   $ 4.40 $ 4.76  
Forfeited, weighted average exercise price (in dollars per share)   2.89 3.81  
Expired, weighted average exercise price (in dollars per share)   4.91 4.26  
Granted, weighted average exercise price (in dollars per share)   2.14 2.93  
Exercised, weighted average exercise price (in dollars per share)   0 2.03  
Options outstanding, vested and expected to vest, weighted average exercise price, ending balance (in dollars per share)   3.93 $ 4.40  
Options exercisable, weighted average exercise price (in dollars per share)   $ 4.54    
Stock Options [Member] | Minimum [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Expected term   5 years 6 months 5 years 6 months  
Volatility   68.00% 62.00%  
Risk-free interest rate   0.80% 0.33%  
Stock Options [Member] | Maximum [Member]        
Fair Value Assumptions and Methodology [Abstract]        
Expected term   6 years 3 months 18 days 6 years 3 months 18 days  
Volatility   70.00% 70.00%  
Risk-free interest rate   1.27% 1.68%  
Restricted Stock Units (RSUs) [Member]        
Stock Option Outstanding and Exercisable [Abstract]        
Unrecognized compensation expense, non option     $ 5,100,000  
Unrecognized compensation expense recognition period     2 years 7 months 6 days  
Restricted Stock Units [Abstract]        
Shares withheld for tax withholding obligation (in shares)   27,850    
Amount of shares withheld for tax withholding obligation   $ 62,000    
Unvested RSU, Shares [Abstract]        
Beginning balance (in shares)   326,000 0  
Granted (in shares)   4,384,744 361,000  
Vested (in shares)   (92,750) (15,000)  
Forfeited (in shares)   (132,861) (20,000)  
Ending balance (in shares)   4,485,133 326,000  
Unvested RSU, Weighted Average Grant Date Fair Value        
Unvested, Weighted average grant date fair value, beginning balance (in dollars per share)   $ 2.81 $ 0  
Granted, Weighted average grant date fair value (in dollars per share)   1.30 2.82  
Vested, Weighted average grant date fair value (in dollars per share)   2.82 2.92  
Forfeited, Weighted average grant date fair value (in dollars per share)   2.51 2.83  
Unvested, Weighted average grant date fair value, ending balance (in dollars per share)   $ 1.34 $ 2.81  
Restricted Stock Units (RSUs) [Member] | Employees [Member]        
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period   4 years    
Restricted Stock Units (RSUs) [Member] | Directors [Member]        
Restricted Stock Units [Abstract]        
Restricted stock units vested over a period   1 year    
Restricted Stock Units (RSUs) [Member] | Employee Retention Program [Member]        
Restricted Stock Units [Abstract]        
Number of restricted stock units granted (in shares)   3,832,500    
Time Based Restricted Stock (RSUs) [Member] | Employee Retention Program [Member]        
Restricted Stock Units [Abstract]        
Number of restricted stock units granted (in shares)   2,685,000    
Time Based Restricted Stock (RSUs) [Member] | Employee Retention Program [Member] | Tranche One [Member]        
Restricted Stock Units [Abstract]        
Vesting percentage of RSUs granted under retention bonus program   50.00%    
Milestone Based Restricted Stock (RSUs) [Member] | Subsequent Event [Member]        
Unvested RSU, Shares [Abstract]        
Vested (in shares) (254,745)      
Milestone Based Restricted Stock (RSUs) [Member] | Employee Retention Program [Member]        
Restricted Stock Units [Abstract]        
Number of restricted stock units granted (in shares)   1,147,500