Annual report pursuant to Section 13 and 15(d)

STOCKHOLDERS EQUITY (Details Narrative)

v3.21.1
STOCKHOLDERS EQUITY (Details Narrative) - USD ($)
1 Months Ended 12 Months Ended
Feb. 11, 2020
Feb. 21, 2020
May 21, 2019
May 02, 2019
Dec. 31, 2020
Dec. 31, 2019
Nov. 05, 2020
Aug. 05, 2020
Aug. 23, 2019
Preferred stock, par value         $ 0.0001 $ 0.0001      
Preferred stock, shares authorized         10,000,000 10,000,000      
Preferred stock, outstanding         0 0      
Stock options exercised, shares         6,626 27,787      
Common stock, par value         $ 0.0001 $ 0.0001      
Common stock, shares issued         104,902,888 59,318,355      
Common stock, shares authorized         150,000,000 150,000,000     150,000,000
Common stock, shares outstanding         104,902,888 59,318,355      
Underwritten public offering 23,500,000 3,525,000 12,937,500            
Proceeds from issuance of shares $ 82,300,000 $ 12,300,000 $ 51,800,000   $ 131,195,291 $ 48,397,088      
Net proceeds from the issuance of common stock   $ 88,700,000 $ 48,400,000            
Common stock issuable         30,655,784        
Warrants outstanding         4,528,160 2,138,160      
Weighted average exercise price of warrants         $ 2.82 $ 3.81      
Dividend yield         0.00% 0.00%      
Compensation expense         $ 900,000 $ 700,000      
Restricted stock units [Member]                  
Unrecognized compensation expense recognition period         3 years 2 months 12 days        
Unrecognized compensation expense         $ 4,000,000.0        
Compensation expense         $ 300,000        
Common stock granted         361,000        
Perceptive Tranche IV Warrant [Member]                  
Warrant exercise price per share         $ 1.94        
Dividend yield         0.00%        
Expected term         10 years        
Fair value of warrants         $ 3,700,000        
Shares issued upon exercise of warrants, Amount         $ 2,390,000        
Risk-free interest rate         0.92%        
Volatility         69.30%        
Perceptive Tranche III Warrant [Member]                  
Warrant exercise price per share       $ 4.64          
Fair value of warrants       $ 900,000          
Shares issued upon exercise of warrants, Amount       $ 250,000          
January 1, 2021 [Member]                  
Shares issuance         6,860,353        
May 3, 2019 [Member] | Perceptive Tranche III Warrant [Member]                  
Warrant exercise price per share         $ 4.64        
Dividend yield         0.00%        
Expected term         10 years        
Fair value of warrants         $ 900,000        
Shares issued upon exercise of warrants, Amount         $ 250,000        
Risk-free interest rate         2.54%        
Volatility         62.30%        
Perceptive Credit Agreement [Member]                  
Warrant exercise price per share         $ 3.28        
Dividend yield         0.00%        
Expected term         10 years        
Fair value of warrants         $ 2,700,000        
Shares issued upon exercise of warrants, Amount         $ 1,360,000        
Risk-free interest rate         2.65%        
Volatility         61.20%        
Sale Agreement [Member]                  
Proceeds from issuance of shares         $ 42,500,000        
Common stock issuable under agreement             20,000,000 50,000,000  
Common stock shares sold during the period         18,537,907        
Equity Incentive Plans [Member]                  
Shares issuance         2,664,237        
Unrecognized compensation expense recognition period         2 years 3 months 18 days        
Description maximum number of shares reserved for grant         (a) 2,334,940 shares, less any shares available as of such date for issuance under the 2007 Plan; plus (b) an annual increase as of the first day of the Company’s fiscal year, beginning in 2018 and occurring each year thereafter through 2022, equal to 4% of the outstanding shares of common stock as of the end of the Company’s immediately preceding fiscal year, or any lesser number of shares determined by the Board; provided, however, that no more than an aggregate of 10 million shares of common stock may be issued pursuant to incentive stock options intended to qualify under Section 422 of the Internal Revenue Code.        
Weighted average remaining contractual life of stock options outstanding         6 years 6 months 5 years 4 months 24 days      
Unrecognized compensation expense         $ 700,000        
Stock-based compensation expense         $ 2,900,000 $ 2,700,000